Beilstein J. Org. Chem.2011,7, 1070–1074, doi:10.3762/bjoc.7.123
building block 2,2-difluoro-2-(phenylthio)acetic acid (2) as one component, followed by removal of the phenylsulfanyl protecting group in the presence of tributyltin hydride and azobisisobutyronitrile.
Keywords: difluoromethylfunctionality; gem-difluoromethylene-containing acid; pseudopeptides; reductive
often drastically alters the chemical, physical, and biological properties of the parent compounds [6][7][8][9]. Nowadays, difluoromethyl-containing compounds are increasingly being applied in pharmaceuticals and agrochemicals [10][11][12]. It is reported that difluoromethylfunctionality (CF2H) is
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Graphical Abstract
Figure 1:
Two examples of bioactive pseudopeptides bearing a CF2H group.